Plasmodium (falciparum/mixed malaria) Antigen Test Kit

Application

It is suitable for quantitative determination of Plasmodium (falciparum/mixed malaria) antigen in human plasma or whole blood in vitro.

Package

1 test/kit, 5 tests/kit, 10 tests/kit, 25 tests/kit, 50 tests/kit.

Glossary

Plasmodium is divided into Plasmodium vivax, Plasmodium vivax, Plasmodium falciparum and Plasmodium ovale. After the malaria parasite is transmitted to the human body through the Anopheles mosquito, the human body develops malaria, and the human body also produces corresponding specific antibodies. Detection of Plasmodium antibodies and antigens is helpful in diagnosing malaria.

Clinical Significance

Plasmodium antibody positive indicates recent Plasmodium infection. However, a negative test for malaria parasite antibodies is not enough to deny malaria. Antigen tests or smear methods should be done to find malaria parasites. This is meaningful for retrospective analysis and epidemiological investigations

Components

The kit consists of Plasmodium antigen detection card, instruction manual, desiccant, aluminum foil bag and sample diluent.

Plasmodium (falciparum/mixed malaria)

Plasmodium is the causative agent of malaria. Malaria is an insect-borne infectious disease caused by the infection of Plasmodium through the bite of Anopheles mosquitoes or the blood of people with Plasmodium. There are four kinds of Plasmodium parasites in human body, namely Plasmodium vivax, Plasmodium malaria, Plasmodium falciparum and Plasmodium ovale. In my country, it is mainly Plasmodium vivax and Plasmodium falciparum.

Prevention：

Drugs: chloroquine; pyrimethamine + sulfadoxine

Mosquito repellent.

Vaccines: 1. sporozoite vaccine 2. merozoite vaccine 3. gametophyte vaccine.

Development direction: 1. Multivalent vaccine; 2. Antivirus vaccine; 3. DNA vaccine.

treatment：Plasmodium vivax: Chloroquine treatment; anti-relapse with primaquine, because of its effect on ectoparasites.

Plasmodium falciparum: Chloroquine; combination therapy for resistant strains.

Mode of infection:

(1) Source of infection: Patients with gametophytes and carriers in peripheral blood are the source of infection for malaria. The gametophyte of Plasmodium vivax often appears 2 to 3 days after the protozoaemia, while the gametophyte of Plasmodium falciparum appears late in the peripheral blood, and only appears 7 to 11 days after the protozoaemia, and the blood with intracellular plasmodium. Blood donors can also transmit malaria through their blood supply.

(2) Malaria transmission vector: Anopheles mosquito is the transmission vector of malaria. The main Anopheles sinensis mosquitoes in China are Anopheles sinensis, Anopheles anthropophagus, Anopheles parvum and Anopheles grandis.

Susceptible population: Except for those who are not susceptible to a certain type of Plasmodium due to certain genetic factors and infants in high malaria areas can acquire certain resistance from their mothers, other populations are generally susceptible to human Plasmodium. Repeated malaria infection can make the body develop a certain protective immunity, so the incidence rate of adults in malaria areas is lower than that of children, and foreign non-immune populations can often cause malaria outbreaks.

In addition to the above three basic links, the transmission intensity of malaria is also affected by natural and social factors. Among the natural factors, temperature and rainfall are the most important, and suitable temperature and rainfall affect the number and blood-sucking activities of Anopheles mosquitoes and the development of protozoa in Anopheles mosquitoes. One of the reasons for the resurgence of the epidemic is the global warming, which has prolonged the transmission season of insect vectors. Social factors such as politics, economy, culture, health level and human social activities directly or indirectly affect the spread and prevalence of malaria. The rise of the epidemic in some areas of my country is mainly due to the increase in the floating population after economic development and the increase in imported cases, causing the spread of the source of infection.

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